Lipopolysaccharide (LPS) causes a systemic inflammatory response, which is characterized by high mortality and few signs, including metabolic disorders, respiratory acidosis, hypotension, and disruption of vital organs. Cytokine secretion and oxidative stress are the main features of this disease. Diagnosis and treatment of systemic inflammation (SI) remains a challenge. Korean Red Ginseng (RG) is one of the medicinal plants that show strong anti-oxidant effects. We aimed to study the protective effects of GM on systemic inflammatory response in mice and RAW 264.7 macrophages induced by LPS.
Mice treated with water and alcohol extract of RG for four weeks to prevent the inflammatory response. The results showed that the LPS toxin increased morbidity and mortality, and induced liver, kidney, and injured lungs manifested by biomarker deteriorated. Hypotension, hypomagnesemia, acidosis, and oxidative stress observed in septic rats. However, RG extract attenuated liver, kidney, and lung enzymes and metabolites in the group treated with anti-inflammatory and anti-oxidant. Furthermore, RG enhanced magnesium and blood pressure in the treatment group.
RAW 264.7 macrophages exposed to LPS interference in translocation and MAPK p65 / p38. However, the RG-pretreated cells was not significantly changed. In conclusion, RG reducing mortality and morbidity rates of treated mice – liver, kidney, and lung injury are protected in the treatment group through potentiation of anti-oxidant defense. RG is able to save on mitochondrial function, inhibits the activation of MAPK / p38 signaling and suppressing NF κ B p65-core cytoplasmic transport. Further studies are needed to examine the effect on chronic conditions in animal models and humans.
Docking protein-1 promotes macrophage inflammatory signaling in gastric cancer.
Docking protein-1 (DOK1) is a tumor suppressor that is often missing in the malignant cells, however, still have the ability to control the activities of immune receptors on cells adjacent stroma of the tumor microenvironment. Therefore, we hypothesized that overcome DOK1 may be useful for cancer immunotherapy. DOK1 DOK1 mRNA and protein expression were downregulated in tumor cells of gastric cancer patients (n = 249). In contrast, expression of the rise and set in the positive case of Epstein Barr Virus (EBV +) together with genes associated with macrophage biology and clinical immunotherapy targets such as programmed cell death-ligand-1 (PD-L1).
In particular, the positive high DOK1 in stromal cells given poor prognosis for patients and correlated with high levels of inducible nitric oxide synthase in CD68 + tumor-associated macrophages. In macrophages derived from leukemia cell lines monocytic human, DOK1 (i) is induced by agonist anti-diabetic transcription factor peroxisome proliferator-activated receptor-gamma (PPAR?), (Ii) an increase in polarization towards the phenotype of inflammation, (iii) plus transcription factor -kB nuclear dependent pro-inflammatory cytokines and (iv) reduce the expression of PD-L1.
Recombinant (E.Coli) Murine Macrophage Inflammatory protein-1 alpha (CCL3) |
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RP-1024 | Alpha Diagnostics | 10 ug | EUR 343.2 |
Recombinant (E.Coli) Human Macrophage Inflammatory protein-1 alpha (CCL3), His-tag |
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RP-1048 | Alpha Diagnostics | 10 ug | EUR 343.2 |
Macrophage Inflammatory Protein-3 alpha (CCL20) |
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PR27176 | Neuromics | 20 ug | EUR 381.6 |
Recombinant (E.Coli) Human Macrophage Inflammatory protein-3 beta (CCL19) |
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RP-1010 | Alpha Diagnostics | 5 ug | EUR 196.8 |
Recombinant (E.Coli) Mouse Macrophage Inflammatory protein-3 beta (CCL19) |
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RP-1043 | Alpha Diagnostics | 5 ug | EUR 196.8 |
Macrophage Inflammatory Protein 3 Alpha (MIP3a) Antibody |
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20-abx104129 | Abbexa |
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Macrophage Inflammatory Protein 3 Alpha (MIP3a) Antibody |
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20-abx104130 | Abbexa |
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Macrophage Inflammatory Protein 3 Alpha (MIP3a) Antibody |
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20-abx128910 | Abbexa |
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Macrophage Inflammatory Protein 3 Alpha (MIP3a) Antibody |
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20-abx130148 | Abbexa |
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Macrophage Inflammatory Protein 3 Alpha (MIP3a) Antibody |
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20-abx131764 | Abbexa |
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Macrophage Inflammatory Protein 3 Alpha (MIP3a) Antibody |
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20-abx131765 | Abbexa |
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Macrophage Inflammatory Protein 3 Alpha (MIP3a) Antibody |
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20-abx173426 | Abbexa |
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Macrophage Inflammatory Protein 3 Alpha (MIP3a) Antibody |
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20-abx177424 | Abbexa |
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Macrophage Inflammatory Protein 3 Alpha (MIP3a) Antibody |
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20-abx177425 | Abbexa |
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Macrophage Inflammatory Protein 3 Alpha (MIP3a) Antibody |
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20-abx177426 | Abbexa |
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Macrophage Inflammatory Protein 3 Alpha (MIP3a) Antibody |
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20-abx177427 | Abbexa |
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Macrophage Inflammatory Protein-3 Alpha (MIP-3a) |
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GWB-D30F39 | GenWay Biotech | 0.02 mg | Ask for price |
Macrophage Inflammatory protein-3 alpha (CCL20) Protein |
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20-abx261545 | Abbexa |
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Macrophage Inflammatory protein-3 alpha (CCL20) Protein |
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20-abx261594 | Abbexa |
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Macrophage Inflammatory protein-3 alpha (CCL20) Protein |
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20-abx262350 | Abbexa |
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Macrophage Inflammatory protein-3 alpha (CCL20) Protein |
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abx261545-100g | Abbexa | 100 µg | EUR 3550 |
Macrophage Inflammatory protein-3 alpha (CCL20) Protein |
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abx261545-10g | Abbexa | 10 µg | EUR 325 |
Macrophage Inflammatory protein-3 alpha (CCL20) Protein |
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abx261545-2g | Abbexa | 2 µg | EUR 225 |
Macrophage Inflammatory protein-3 alpha (CCL20) Protein |
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abx262350-10mg | Abbexa | 10 mg | EUR 6575 |
Macrophage Inflammatory protein-3 alpha (CCL20) Protein |
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abx262350-5mg | Abbexa | 5 mg | EUR 325 |
Recombinant (E.Coli) Human Macrophage Inflammatory protein-4 (CCL18) |
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RP-1025 | Alpha Diagnostics | 10 ug | EUR 343.2 |
Active Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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APA095Hu01 | Cloud-Clone | 10ug | EUR 191 |
Active Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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4-APA095Hu01 | Cloud-Clone |
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Description: Recombinant Human Active Macrophage Inflammatory Protein 3 Alpha (MIP3a) expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells |
Active Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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APA095Hu02 | Cloud-Clone | 10ug | EUR 346 |
Active Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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4-APA095Hu02 | Cloud-Clone |
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Description: Recombinant Human Macrophage Inflammatory Protein 3 Alpha expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells |
Active Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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RPU55479-100ug | Biomatik Corporation | 100ug | EUR 589.6 |
Active Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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RPU55479-1mg | Biomatik Corporation | 1mg | EUR 2982.2 |
Active Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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RPU55479-50ug | Biomatik Corporation | 50ug | EUR 458.9 |
Active Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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RPU55480-100ug | Biomatik Corporation | 100ug | EUR 1063.7 |
Active Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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RPU55480-1mg | Biomatik Corporation | 1mg | EUR 5391.1 |
Active Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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RPU55480-50ug | Biomatik Corporation | 50ug | EUR 829.5 |
Active Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2105073-001mg | MyBiosource | 0.01mg | EUR 175 |
Active Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2105073-005mg | MyBiosource | 0.05mg | EUR 325 |
Active Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2105073-01mg | MyBiosource | 0.1mg | EUR 495 |
Active Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2105073-02mg | MyBiosource | 0.2mg | EUR 605 |
Active Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2105073-05mg | MyBiosource | 0.5mg | EUR 1155 |
Active Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2105074-001mg | MyBiosource | 0.01mg | EUR 260 |
Active Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2105074-005mg | MyBiosource | 0.05mg | EUR 555 |
Active Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2105074-01mg | MyBiosource | 0.1mg | EUR 850 |
Active Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2105074-02mg | MyBiosource | 0.2mg | EUR 1055 |
Active Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2105074-05mg | MyBiosource | 0.5mg | EUR 2050 |
Rat Macrophage Inflammatory Protein 3 Alpha CLIA Kit |
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MBS8426860-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Anti-CCL3/Macrophage Inflammatory Protein 1 alpha Antibody |
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PB9571 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-CCL3/Macrophage Inflammatory Protein 1 alpha Antibody |
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PB9022 | BosterBio | 100ug/vial | EUR 352.8 |
Rat Macrophage Inflammatory Protein 3 Alpha ELISA Kit |
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IRTMIP3AKT | Innovative research | each | EUR 718 |
Description: Rat Macrophage Inflammatory Protein 3 Alpha ELISA Kit |
Rat Macrophage Inflammatory Protein 3 Alpha ELISA Kit |
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MBS762864-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3900 |
Rat Macrophage Inflammatory Protein 3 Alpha ELISA Kit |
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MBS762864-48StripWells | MyBiosource | 48-Strip-Wells | EUR 340 |
Rat Macrophage Inflammatory Protein 3 Alpha ELISA Kit |
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MBS762864-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2045 |
Rat Macrophage Inflammatory Protein 3 Alpha ELISA Kit |
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MBS762864-96StripWells | MyBiosource | 96-Strip-Wells | EUR 455 |
Rat Macrophage Inflammatory Protein 3 Alpha (MIP3a) Protein |
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20-abx166112 | Abbexa |
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Cow Macrophage Inflammatory Protein 3 Alpha (MIP3a) Protein |
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20-abx654246 | Abbexa |
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Dog Macrophage Inflammatory Protein 3 Alpha (MIP3a) Protein |
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20-abx654247 | Abbexa |
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Pig Macrophage Inflammatory Protein 3 Alpha (MIP3a) Protein |
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20-abx654248 | Abbexa |
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Anti- Macrophage Inflammatory Protein-1 Alpha (MIP-1 alpha) Antibody |
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GWB-464602 | GenWay Biotech | 0.05 mg | Ask for price |
Recombinant (E.Coli) Human Macrophage Inflammatory protein-1 beta (CCL4) |
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RP-1009 | Alpha Diagnostics | 10 ug | EUR 343.2 |
Macrophage Inflammatory Protein 3 Alpha (MIP3a) Antibody (FITC) |
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20-abx273848 | Abbexa |
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Macrophage Inflammatory Protein 3 Alpha (MIP3a) Antibody Pair |
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20-abx370553 | Abbexa |
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Human Macrophage Inflammatory Protein 3 Alpha CLIA Kit |
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MBS8425684-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse Macrophage Inflammatory Protein 3 Alpha CLIA Kit |
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MBS8426385-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Human Macrophage Inflammatory protein-1 alpha |
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90217-A | BPS Bioscience | 5 µg | EUR 130 |
Description: Recombinant MIP-1 alpha is a disulfide-linked homodimeric protein consisting of 70 amino acid residues, and migrates as an approximately 8 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human MIP-1 alpha chain was expressed in E. coli. |
Human Macrophage Inflammatory protein-1 alpha |
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90217-B | BPS Bioscience | 20 µg | EUR 205 |
Description: Recombinant MIP-1 alpha is a disulfide-linked homodimeric protein consisting of 70 amino acid residues, and migrates as an approximately 8 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human MIP-1 alpha chain was expressed in E. coli. |
Human Macrophage Inflammatory Protein 3 Alpha (MIP3a) Protein |
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20-abx067895 | Abbexa |
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Mouse Macrophage Inflammatory Protein 3 Alpha (MIP3a) Protein |
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20-abx067896 | Abbexa |
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Human Macrophage Inflammatory Protein 3 Alpha (MIP3a) Protein |
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20-abx167923 | Abbexa |
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Human Macrophage Inflammatory Protein 3 Alpha ELISA Kit |
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IHUMIP3AKT | Innovative research | each | EUR 496 |
Description: Human Macrophage Inflammatory Protein 3 Alpha ELISA Kit |
Mouse Macrophage Inflammatory Protein 3 Alpha ELISA Kit |
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IMSMIP3AKT | Innovative research | each | EUR 502 |
Description: Mouse Macrophage Inflammatory Protein 3 Alpha ELISA Kit |
Mouse Macrophage Inflammatory Protein 3 Alpha ELISA Kit |
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MBS765868-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3900 |
Mouse Macrophage Inflammatory Protein 3 Alpha ELISA Kit |
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MBS765868-48StripWells | MyBiosource | 48-Strip-Wells | EUR 340 |
Mouse Macrophage Inflammatory Protein 3 Alpha ELISA Kit |
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MBS765868-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2045 |
Mouse Macrophage Inflammatory Protein 3 Alpha ELISA Kit |
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MBS765868-96StripWells | MyBiosource | 96-Strip-Wells | EUR 455 |
Human Macrophage Inflammatory Protein 3 Alpha ELISA Kit |
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MBS760384-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3900 |
Human Macrophage Inflammatory Protein 3 Alpha ELISA Kit |
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MBS760384-48StripWells | MyBiosource | 48-Strip-Wells | EUR 340 |
Human Macrophage Inflammatory Protein 3 Alpha ELISA Kit |
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MBS760384-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2045 |
Human Macrophage Inflammatory Protein 3 Alpha ELISA Kit |
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MBS760384-96StripWells | MyBiosource | 96-Strip-Wells | EUR 455 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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RPU57899-100ug | Biomatik Corporation | 100ug | EUR 521.7 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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RPU57899-1mg | Biomatik Corporation | 1mg | EUR 2421.1 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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RPU57899-50ug | Biomatik Corporation | 50ug | EUR 426.8 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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RPU54297-100ug | Biomatik Corporation | 100ug | EUR 591.8 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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RPU54297-1mg | Biomatik Corporation | 1mg | EUR 2620.8 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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RPU54297-50ug | Biomatik Corporation | 50ug | EUR 475.2 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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RPU54588-100ug | Biomatik Corporation | 100ug | EUR 616 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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RPU54588-1mg | Biomatik Corporation | 1mg | EUR 2730 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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RPU54588-50ug | Biomatik Corporation | 50ug | EUR 495 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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RPA095Hu01 | Cloud-Clone | 10ug | EUR 192 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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4-RPA095Hu01 | Cloud-Clone |
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Description: Recombinant Human Macrophage Inflammatory Protein 3 Alpha expressed in: E.coli |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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RPA095Hu02 | Cloud-Clone | 10ug | EUR 192 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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4-RPA095Hu02 | Cloud-Clone |
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Description: Recombinant Human Macrophage Inflammatory Protein 3 Alpha expressed in: E.coli |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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RPA095Mu01 | Cloud-Clone | 10ug | EUR 198 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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4-RPA095Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Macrophage Inflammatory Protein 3 Alpha expressed in: E.coli |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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RPA095Ra01 | Cloud-Clone | 10ug | EUR 200 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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4-RPA095Ra01 | Cloud-Clone |
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Description: Recombinant Rat Macrophage Inflammatory Protein 3 Alpha expressed in: E.coli |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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RPU42646-100ug | Biomatik Corporation | 100ug | EUR 591.8 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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RPU42646-1mg | Biomatik Corporation | 1mg | EUR 2620.8 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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RPU42646-50ug | Biomatik Corporation | 50ug | EUR 475.2 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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RPU42647-100ug | Biomatik Corporation | 100ug | EUR 611.6 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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RPU42647-1mg | Biomatik Corporation | 1mg | EUR 2707.9 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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RPU42647-50ug | Biomatik Corporation | 50ug | EUR 490.6 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2011256-001mg | MyBiosource | 0.01mg | EUR 180 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2011256-005mg | MyBiosource | 0.05mg | EUR 325 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2011256-01mg | MyBiosource | 0.1mg | EUR 495 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2011256-02mg | MyBiosource | 0.2mg | EUR 610 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2011256-05mg | MyBiosource | 0.5mg | EUR 1160 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2030238-001mg | MyBiosource | 0.01mg | EUR 185 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2030238-005mg | MyBiosource | 0.05mg | EUR 340 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2030238-01mg | MyBiosource | 0.1mg | EUR 515 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2030238-02mg | MyBiosource | 0.2mg | EUR 630 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2030238-05mg | MyBiosource | 0.5mg | EUR 1205 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2030836-001mg | MyBiosource | 0.01mg | EUR 180 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2030836-005mg | MyBiosource | 0.05mg | EUR 325 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2030836-01mg | MyBiosource | 0.1mg | EUR 495 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2030836-02mg | MyBiosource | 0.2mg | EUR 610 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2030836-05mg | MyBiosource | 0.5mg | EUR 1160 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2010144-001mg | MyBiosource | 0.01mg | EUR 180 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2010144-005mg | MyBiosource | 0.05mg | EUR 330 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2010144-01mg | MyBiosource | 0.1mg | EUR 510 |
Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a) |
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MBS2010144-02mg | MyBiosource | 0.2mg | EUR 630 |
This property is empowered DOK1 + macrophages to reduce the viability of human gastric cancer cells in co-culture contact depends. DOK1 also reduces PD-L1 expression in human primary blood monocytes. Our data suggest that drugability of DOK1 can be used to reprogram cells of myeloid and upholding the innate immune response to EBV + cancer.Clostridium difficile infection of human gastric (CDI) causes diarrhea and colitis. We aim to find common pathogenic pathways in the CDI between humans and rats by comparing toxin-mediated effects in humans and mice colon tissues.We determined cytokine secretion toxin A- and B-treated human and mouse colon explants using multiplex A and toxin ELISA.Toxin B exposure to human and mouse explant fresh colon caused by different patterns of secretion of cytokines.