(MIP) belong to the family of chemotactic cytokines
Red Ginseng Reduces Inflammatory Response via Suppression MAPK/P38 Signaling and p65 Nuclear Proteins Translocation in Rats and Raw 264.7 Macrophage.
Lipopolysaccharide (LPS) causes a systemic inflammatory response, which is characterized by high mortality and few signs, including metabolic disorders, respiratory acidosis, hypotension, and disruption of vital organs. Cytokine secretion and oxidative stress are the main features of this disease. Diagnosis and treatment of systemic inflammation (SI) remains a challenge. Korean Red Ginseng (RG) is one of the medicinal plants that show strong anti-oxidant effects. We aimed to study the protective effects of GM on systemic inflammatory response in mice and RAW 264.7 macrophages induced by LPS.
Mice treated with water and alcohol extract of RG for four weeks to prevent the inflammatory response. The results showed that the LPS toxin increased morbidity and mortality, and induced liver, kidney, and injured lungs manifested by biomarker deteriorated. Hypotension, hypomagnesemia, acidosis, and oxidative stress observed in septic rats. However, RG extract attenuated liver, kidney, and lung enzymes and metabolites in the group treated with anti-inflammatory and anti-oxidant. Furthermore, RG enhanced magnesium and blood pressure in the treatment group.
RAW 264.7 macrophages exposed to LPS interference in translocation and MAPK p65 / p38. However, the RG-pretreated cells was not significantly changed. In conclusion, RG reducing mortality and morbidity rates of treated mice – liver, kidney, and lung injury are protected in the treatment group through potentiation of anti-oxidant defense. RG is able to save on mitochondrial function, inhibits the activation of MAPK / p38 signaling and suppressing NF κ B p65-core cytoplasmic transport. Further studies are needed to examine the effect on chronic conditions in animal models and humans.
Red Ginseng Reduces Inflammatory Response via Suppression MAPK/P38 Signaling and p65 Nuclear Proteins Translocation in Rats and Raw 264.7 Macrophage.
Docking protein-1 promotes macrophage inflammatory signaling in gastric cancer.
Docking protein-1 (DOK1) is a tumor suppressor that is often missing in the malignant cells, however, still have the ability to control the activities of immune receptors on cells adjacent stroma of the tumor microenvironment. Therefore, we hypothesized that overcome DOK1 may be useful for cancer immunotherapy. DOK1 DOK1 mRNA and protein expression were downregulated in tumor cells of gastric cancer patients (n = 249). In contrast, expression of the rise and set in the positive case of Epstein Barr Virus (EBV +) together with genes associated with macrophage biology and clinical immunotherapy targets such as programmed cell death-ligand-1 (PD-L1).
In particular, the positive high DOK1 in stromal cells given poor prognosis for patients and correlated with high levels of inducible nitric oxide synthase in CD68 + tumor-associated macrophages. In macrophages derived from leukemia cell lines monocytic human, DOK1 (i) is induced by agonist anti-diabetic transcription factor peroxisome proliferator-activated receptor-gamma (PPAR?), (Ii) an increase in polarization towards the phenotype of inflammation, (iii) plus transcription factor -kB nuclear dependent pro-inflammatory cytokines and (iv) reduce the expression of PD-L1.
Description: Recombinant Human Active Macrophage Inflammatory Protein 3 Alpha (MIP3a) expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells
Active Macrophage Inflammatory Protein 3 Alpha (MIP3a)
Description: Recombinant MIP-1 alpha is a disulfide-linked homodimeric protein consisting of 70 amino acid residues, and migrates as an approximately 8 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human MIP-1 alpha chain was expressed in E. coli.
Description: Recombinant MIP-1 alpha is a disulfide-linked homodimeric protein consisting of 70 amino acid residues, and migrates as an approximately 8 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human MIP-1 alpha chain was expressed in E. coli.
Cow Macrophage Inflammatory Protein 3 Alpha (MIP3a) Protein
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Rat Macrophage Inflammatory Protein 3 Alpha (MIP3a) in serum, plasma and other biological fluids.
Rat Macrophage Inflammatory Protein 3 Alpha (MIP3a)CLIA Kit
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Rat Macrophage Inflammatory Protein 3 Alpha (MIP3a) in serum, plasma and other biological fluids.
Rat Macrophage Inflammatory Protein 3 Alpha (MIP3a)CLIA Kit
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Rat Macrophage Inflammatory Protein 3 Alpha (MIP3a) in serum, plasma and other biological fluids.
Rat Macrophage Inflammatory Protein 3 Alpha (MIP3a)CLIA Kit
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Rat Macrophage Inflammatory Protein 3 Alpha (MIP3a) in serum, plasma and other biological fluids.
Rat Macrophage Inflammatory Protein 3 Alpha (MIP3a) CLIA Kit
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Rat Macrophage Inflammatory Protein 3 Alpha (MIP3a)Serum, plasma and other biological fluids
Rat Macrophage Inflammatory Protein 3 Alpha (MIP3a) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Rat Macrophage Inflammatory Protein 3 Alpha (MIP3a) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Rat Macrophage Inflammatory Protein 3 Alpha (MIP3a) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Rat Macrophage Inflammatory Protein 3 Alpha (MIP3a) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Rat Macrophage Inflammatory Protein 3 Alpha (MIP3a) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Pig Macrophage Inflammatory Protein 3 Alpha (MIP3a) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Pig Macrophage Inflammatory Protein 3 Alpha (MIP3a) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Pig Macrophage Inflammatory Protein 3 Alpha (MIP3a) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Pig Macrophage Inflammatory Protein 3 Alpha (MIP3a) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Pig Macrophage Inflammatory Protein 3 Alpha (MIP3a) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Pig Macrophage Inflammatory Protein 3 Alpha (MIP3a) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Pig Macrophage Inflammatory Protein 3 Alpha (MIP3a) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Pig Macrophage Inflammatory Protein 3 Alpha (MIP3a) ELISA Kit
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Pig Macrophage Inflammatory Protein 3 Alpha (MIP3a) in samples from Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.
Rat Macrophage Inflammatory Protein 3 Alpha (MIP3a) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Macrophage Inflammatory Protein 3 Alpha (MIP3a) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Rat Macrophage Inflammatory Protein 3 Alpha (MIP3a) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Macrophage Inflammatory Protein 3 Alpha (MIP3a) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Rat Macrophage Inflammatory Protein 3 Alpha (MIP3a) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Macrophage Inflammatory Protein 3 Alpha (MIP3a) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Rat Macrophage Inflammatory Protein 3 Alpha (MIP3a) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Macrophage Inflammatory Protein 3 Alpha (MIP3a) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Rat Macrophage Inflammatory Protein 3 Alpha (MIP3a) ELISA Kit
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Macrophage Inflammatory Protein 3 Alpha (MIP3a) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.
Rat Macrophage Inflammatory Protein 3 Alpha (MIP3a) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Human Macrophage Inflammatory Protein 3 Alpha (MIP3a) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Human Macrophage Inflammatory Protein 3 Alpha (MIP3a) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Human Macrophage Inflammatory Protein 3 Alpha (MIP3a) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Mouse Macrophage Inflammatory Protein 3 Alpha (MIP3a) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Macrophage Inflammatory Protein 3 Alpha (MIP3a) in samples from serum, plasma or other biological fluids.
Mouse Macrophage Inflammatory Protein 3 Alpha (MIP3a) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Macrophage Inflammatory Protein 3 Alpha (MIP3a) in samples from serum, plasma or other biological fluids.
Human Macrophage Inflammatory Protein 3 Alpha (MIP3a) ELISA Kit
Description: serum, plasma or other biological fluids.
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This property is empowered DOK1 + macrophages to reduce the viability of human gastric cancer cells in co-culture contact depends. DOK1 also reduces PD-L1 expression in human primary blood monocytes. Our data suggest that drugability of DOK1 can be used to reprogram cells of myeloid and upholding the innate immune response to EBV + cancer.Clostridium difficile infection of human gastric (CDI) causes diarrhea and colitis. We aim to find common pathogenic pathways in the CDI between humans and rats by comparing toxin-mediated effects in humans and mice colon tissues.We determined cytokine secretion toxin A- and B-treated human and mouse colon explants using multiplex A and toxin ELISA.Toxin B exposure to human and mouse explant fresh colon caused by different patterns of secretion of cytokines.
