Red Ginseng Reduces Inflammatory Response via Suppression MAPK/P38 Signaling and p65 Nuclear Proteins Translocation in Rats and Raw 264.7 Macrophage.

Red Ginseng Reduces Inflammatory Response via Suppression MAPK/P38 Signaling and p65 Nuclear Proteins Translocation in Rats and Raw 264.7 Macrophage.

Lipopolysaccharide (LPS) causes a systemic inflammatory response, which is characterized by high mortality and few signs, including metabolic disorders, respiratory acidosis, hypotension, and disruption of vital organs. Cytokine secretion and oxidative stress are the main features of this disease. Diagnosis and treatment of systemic inflammation (SI) remains a challenge. Korean Red Ginseng (RG) is one of the medicinal plants that show strong anti-oxidant effects. We aimed to study the protective effects of GM on systemic inflammatory response in mice and RAW 264.7 macrophages induced by LPS.

Mice treated with water and alcohol extract of RG for four weeks to prevent the inflammatory response. The results showed that the LPS toxin increased morbidity and mortality, and induced liver, kidney, and injured lungs manifested by biomarker deteriorated. Hypotension, hypomagnesemia, acidosis, and oxidative stress observed in septic rats. However, RG extract attenuated liver, kidney, and lung enzymes and metabolites in the group treated with anti-inflammatory and anti-oxidant. Furthermore, RG enhanced magnesium and blood pressure in the treatment group.

RAW 264.7 macrophages exposed to LPS interference in translocation and MAPK p65 / p38. However, the RG-pretreated cells was not significantly changed. In conclusion, RG reducing mortality and morbidity rates of treated mice – liver, kidney, and lung injury are protected in the treatment group through potentiation of anti-oxidant defense. RG is able to save on mitochondrial function, inhibits the activation of MAPK / p38 signaling and suppressing NF κ B p65-core cytoplasmic transport. Further studies are needed to examine the effect on chronic conditions in animal models and humans.

Red Ginseng Reduces Inflammatory Response via Suppression MAPK/P38 Signaling and p65 Nuclear Proteins Translocation in Rats and Raw 264.7 Macrophage.
Red Ginseng Reduces Inflammatory Response via Suppression MAPK/P38 Signaling and p65 Nuclear Proteins Translocation in Rats and Raw 264.7 Macrophage.

Docking protein-1 promotes macrophage inflammatory signaling in gastric cancer.

Docking protein-1 (DOK1) is a tumor suppressor that is often missing in the malignant cells, however, still have the ability to control the activities of immune receptors on cells adjacent stroma of the tumor microenvironment. Therefore, we hypothesized that overcome DOK1 may be useful for cancer immunotherapy. DOK1 DOK1 mRNA and protein expression were downregulated in tumor cells of gastric cancer patients (n = 249). In contrast, expression of the rise and set in the positive case of Epstein Barr Virus (EBV +) together with genes associated with macrophage biology and clinical immunotherapy targets such as programmed cell death-ligand-1 (PD-L1).

In particular, the positive high DOK1 in stromal cells given poor prognosis for patients and correlated with high levels of inducible nitric oxide synthase in CD68 + tumor-associated macrophages. In macrophages derived from leukemia cell lines monocytic human, DOK1 (i) is induced by agonist anti-diabetic transcription factor peroxisome proliferator-activated receptor-gamma (PPAR?), (Ii) an increase in polarization towards the phenotype of inflammation, (iii) plus transcription factor -kB nuclear dependent pro-inflammatory cytokines and (iv) reduce the expression of PD-L1.

Recombinant (E.Coli) Murine Macrophage Inflammatory protein-1 alpha (CCL3)

RP-1024 10 ug
EUR 343.2

Recombinant (E.Coli) Human Macrophage Inflammatory protein-1 alpha (CCL3), His-tag

RP-1048 10 ug
EUR 343.2

Macrophage Inflammatory Protein-3 alpha (CCL20)

PR27176 20 ug
EUR 381.6

Recombinant (E.Coli) Human Macrophage Inflammatory protein-3 beta (CCL19)

RP-1010 5 ug
EUR 196.8

Recombinant (E.Coli) Mouse Macrophage Inflammatory protein-3 beta (CCL19)

RP-1043 5 ug
EUR 196.8

Macrophage Inflammatory Protein 3 Alpha (MIP3a) Antibody

20-abx104129
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Macrophage Inflammatory Protein 3 Alpha (MIP3a) Antibody

20-abx104130
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Macrophage Inflammatory Protein 3 Alpha (MIP3a) Antibody

20-abx128910
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Macrophage Inflammatory Protein 3 Alpha (MIP3a) Antibody

20-abx130148
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Macrophage Inflammatory Protein 3 Alpha (MIP3a) Antibody

20-abx131764
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Macrophage Inflammatory Protein 3 Alpha (MIP3a) Antibody

20-abx131765
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Macrophage Inflammatory Protein 3 Alpha (MIP3a) Antibody

20-abx173426
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Macrophage Inflammatory Protein 3 Alpha (MIP3a) Antibody

20-abx177424
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Macrophage Inflammatory Protein 3 Alpha (MIP3a) Antibody

20-abx177425
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Macrophage Inflammatory Protein 3 Alpha (MIP3a) Antibody

20-abx177426
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Macrophage Inflammatory Protein 3 Alpha (MIP3a) Antibody

20-abx177427
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Macrophage Inflammatory Protein-3 Alpha (MIP-3a)

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Macrophage Inflammatory protein-3 alpha (CCL20) Protein

20-abx261545
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Macrophage Inflammatory protein-3 alpha (CCL20) Protein

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Macrophage Inflammatory protein-3 alpha (CCL20) Protein

20-abx262350
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Macrophage Inflammatory protein-3 alpha (CCL20) Protein

abx261545-100g 100 µg
EUR 3550

Macrophage Inflammatory protein-3 alpha (CCL20) Protein

abx261545-10g 10 µg
EUR 325

Macrophage Inflammatory protein-3 alpha (CCL20) Protein

abx261545-2g 2 µg
EUR 225

Macrophage Inflammatory protein-3 alpha (CCL20) Protein

abx262350-10mg 10 mg
EUR 6575

Macrophage Inflammatory protein-3 alpha (CCL20) Protein

abx262350-5mg 5 mg
EUR 325

Recombinant (E.Coli) Human Macrophage Inflammatory protein-4 (CCL18)

RP-1025 10 ug
EUR 343.2

Active Macrophage Inflammatory Protein 3 Alpha (MIP3a)

APA095Hu01 10ug
EUR 191

Active Macrophage Inflammatory Protein 3 Alpha (MIP3a)

4-APA095Hu01
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Description: Recombinant Human Active Macrophage Inflammatory Protein 3 Alpha (MIP3a) expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Macrophage Inflammatory Protein 3 Alpha (MIP3a)

APA095Hu02 10ug
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Active Macrophage Inflammatory Protein 3 Alpha (MIP3a)

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Description: Recombinant Human Macrophage Inflammatory Protein 3 Alpha expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Macrophage Inflammatory Protein 3 Alpha (MIP3a)

RPU55479-100ug 100ug
EUR 589.6

Active Macrophage Inflammatory Protein 3 Alpha (MIP3a)

RPU55479-1mg 1mg
EUR 2982.2

Active Macrophage Inflammatory Protein 3 Alpha (MIP3a)

RPU55479-50ug 50ug
EUR 458.9

Active Macrophage Inflammatory Protein 3 Alpha (MIP3a)

RPU55480-100ug 100ug
EUR 1063.7

Active Macrophage Inflammatory Protein 3 Alpha (MIP3a)

RPU55480-1mg 1mg
EUR 5391.1

Active Macrophage Inflammatory Protein 3 Alpha (MIP3a)

RPU55480-50ug 50ug
EUR 829.5

Active Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2105073-001mg 0.01mg
EUR 175

Active Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2105073-005mg 0.05mg
EUR 325

Active Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2105073-01mg 0.1mg
EUR 495

Active Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2105073-02mg 0.2mg
EUR 605

Active Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2105073-05mg 0.5mg
EUR 1155

Active Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2105074-001mg 0.01mg
EUR 260

Active Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2105074-005mg 0.05mg
EUR 555

Active Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2105074-01mg 0.1mg
EUR 850

Active Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2105074-02mg 0.2mg
EUR 1055

Active Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2105074-05mg 0.5mg
EUR 2050

Rat Macrophage Inflammatory Protein 3 Alpha CLIA Kit

MBS8426860-INQUIRE INQUIRE Ask for price

Anti-CCL3/Macrophage Inflammatory Protein 1 alpha Antibody

PB9571 100ug/vial
EUR 352.8

Anti-CCL3/Macrophage Inflammatory Protein 1 alpha Antibody

PB9022 100ug/vial
EUR 352.8

Rat Macrophage Inflammatory Protein 3 Alpha ELISA Kit

IRTMIP3AKT each
EUR 718
Description: Rat Macrophage Inflammatory Protein 3 Alpha ELISA Kit

Rat Macrophage Inflammatory Protein 3 Alpha ELISA Kit

MBS762864-10x96StripWells 10x96-Strip-Wells
EUR 3900

Rat Macrophage Inflammatory Protein 3 Alpha ELISA Kit

MBS762864-48StripWells 48-Strip-Wells
EUR 340

Rat Macrophage Inflammatory Protein 3 Alpha ELISA Kit

MBS762864-5x96StripWells 5x96-Strip-Wells
EUR 2045

Rat Macrophage Inflammatory Protein 3 Alpha ELISA Kit

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EUR 455

Rat Macrophage Inflammatory Protein 3 Alpha (MIP3a) Protein

20-abx166112
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Cow Macrophage Inflammatory Protein 3 Alpha (MIP3a) Protein

20-abx654246
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Dog Macrophage Inflammatory Protein 3 Alpha (MIP3a) Protein

20-abx654247
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Pig Macrophage Inflammatory Protein 3 Alpha (MIP3a) Protein

20-abx654248
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Anti- Macrophage Inflammatory Protein-1 Alpha (MIP-1 alpha) Antibody

GWB-464602 0.05 mg Ask for price

Recombinant (E.Coli) Human Macrophage Inflammatory protein-1 beta (CCL4)

RP-1009 10 ug
EUR 343.2

Macrophage Inflammatory Protein 3 Alpha (MIP3a) Antibody (FITC)

20-abx273848
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Macrophage Inflammatory Protein 3 Alpha (MIP3a) Antibody Pair

20-abx370553
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Human Macrophage Inflammatory Protein 3 Alpha CLIA Kit

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Mouse Macrophage Inflammatory Protein 3 Alpha CLIA Kit

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Human Macrophage Inflammatory protein-1 alpha

90217-A 5 µg
EUR 130
Description: Recombinant MIP-1 alpha is a disulfide-linked homodimeric protein consisting of 70 amino acid residues, and migrates as an approximately 8 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human MIP-1 alpha chain was expressed in E. coli.

Human Macrophage Inflammatory protein-1 alpha

90217-B 20 µg
EUR 205
Description: Recombinant MIP-1 alpha is a disulfide-linked homodimeric protein consisting of 70 amino acid residues, and migrates as an approximately 8 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human MIP-1 alpha chain was expressed in E. coli.

Human Macrophage Inflammatory Protein 3 Alpha (MIP3a) Protein

20-abx067895
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Mouse Macrophage Inflammatory Protein 3 Alpha (MIP3a) Protein

20-abx067896
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Human Macrophage Inflammatory Protein 3 Alpha (MIP3a) Protein

20-abx167923
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Human Macrophage Inflammatory Protein 3 Alpha ELISA Kit

IHUMIP3AKT each
EUR 496
Description: Human Macrophage Inflammatory Protein 3 Alpha ELISA Kit

Mouse Macrophage Inflammatory Protein 3 Alpha ELISA Kit

IMSMIP3AKT each
EUR 502
Description: Mouse Macrophage Inflammatory Protein 3 Alpha ELISA Kit

Mouse Macrophage Inflammatory Protein 3 Alpha ELISA Kit

MBS765868-10x96StripWells 10x96-Strip-Wells
EUR 3900

Mouse Macrophage Inflammatory Protein 3 Alpha ELISA Kit

MBS765868-48StripWells 48-Strip-Wells
EUR 340

Mouse Macrophage Inflammatory Protein 3 Alpha ELISA Kit

MBS765868-5x96StripWells 5x96-Strip-Wells
EUR 2045

Mouse Macrophage Inflammatory Protein 3 Alpha ELISA Kit

MBS765868-96StripWells 96-Strip-Wells
EUR 455

Human Macrophage Inflammatory Protein 3 Alpha ELISA Kit

MBS760384-10x96StripWells 10x96-Strip-Wells
EUR 3900

Human Macrophage Inflammatory Protein 3 Alpha ELISA Kit

MBS760384-48StripWells 48-Strip-Wells
EUR 340

Human Macrophage Inflammatory Protein 3 Alpha ELISA Kit

MBS760384-5x96StripWells 5x96-Strip-Wells
EUR 2045

Human Macrophage Inflammatory Protein 3 Alpha ELISA Kit

MBS760384-96StripWells 96-Strip-Wells
EUR 455

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

RPU57899-100ug 100ug
EUR 521.7

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

RPU57899-1mg 1mg
EUR 2421.1

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

RPU57899-50ug 50ug
EUR 426.8

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

RPU54297-100ug 100ug
EUR 591.8

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

RPU54297-1mg 1mg
EUR 2620.8

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

RPU54297-50ug 50ug
EUR 475.2

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

RPU54588-100ug 100ug
EUR 616

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

RPU54588-1mg 1mg
EUR 2730

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

RPU54588-50ug 50ug
EUR 495

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

RPA095Hu01 10ug
EUR 192

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

4-RPA095Hu01
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Description: Recombinant Human Macrophage Inflammatory Protein 3 Alpha expressed in: E.coli

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

RPA095Hu02 10ug
EUR 192

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

4-RPA095Hu02
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Description: Recombinant Human Macrophage Inflammatory Protein 3 Alpha expressed in: E.coli

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

RPA095Mu01 10ug
EUR 198

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

4-RPA095Mu01
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Description: Recombinant Mouse Macrophage Inflammatory Protein 3 Alpha expressed in: E.coli

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

RPA095Ra01 10ug
EUR 200

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

4-RPA095Ra01
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Description: Recombinant Rat Macrophage Inflammatory Protein 3 Alpha expressed in: E.coli

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

RPU42646-100ug 100ug
EUR 591.8

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

RPU42646-1mg 1mg
EUR 2620.8

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

RPU42646-50ug 50ug
EUR 475.2

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

RPU42647-100ug 100ug
EUR 611.6

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

RPU42647-1mg 1mg
EUR 2707.9

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

RPU42647-50ug 50ug
EUR 490.6

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2011256-001mg 0.01mg
EUR 180

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2011256-005mg 0.05mg
EUR 325

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2011256-01mg 0.1mg
EUR 495

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2011256-02mg 0.2mg
EUR 610

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2011256-05mg 0.5mg
EUR 1160

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2030238-001mg 0.01mg
EUR 185

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2030238-005mg 0.05mg
EUR 340

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2030238-01mg 0.1mg
EUR 515

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2030238-02mg 0.2mg
EUR 630

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2030238-05mg 0.5mg
EUR 1205

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2030836-001mg 0.01mg
EUR 180

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2030836-005mg 0.05mg
EUR 325

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2030836-01mg 0.1mg
EUR 495

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2030836-02mg 0.2mg
EUR 610

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2030836-05mg 0.5mg
EUR 1160

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2010144-001mg 0.01mg
EUR 180

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2010144-005mg 0.05mg
EUR 330

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2010144-01mg 0.1mg
EUR 510

Recombinant Macrophage Inflammatory Protein 3 Alpha (MIP3a)

MBS2010144-02mg 0.2mg
EUR 630

This property is empowered DOK1 + macrophages to reduce the viability of human gastric cancer cells in co-culture contact depends. DOK1 also reduces PD-L1 expression in human primary blood monocytes. Our data suggest that drugability of DOK1 can be used to reprogram cells of myeloid and upholding the innate immune response to EBV + cancer.Clostridium difficile infection of human gastric (CDI) causes diarrhea and colitis. We aim to find common pathogenic pathways in the CDI between humans and rats by comparing toxin-mediated effects in humans and mice colon tissues.We determined cytokine secretion toxin A- and B-treated human and mouse colon explants using multiplex A and toxin ELISA.Toxin B exposure to human and mouse explant fresh colon caused by different patterns of secretion of cytokines.

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